Publications (2008-present)

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Increased CFTR expression and function from an optimized lentiviral vector for cystic fibrosis gene therapy.
Marquez Loza LI, Cooney AL, Dong Q, Randak CO, Rivella S, Sinn PL, McCray PB Jr.Mol Ther Methods Clin Dev. 2021 Feb 27;21:94-106. doi: 10.1016/j.omtm.2021.02.020. eCollection 2021 Jun 11.
PMID: 33768133 

Adeno-Associated Virus-Based Gene Therapy for Lifelong Correction of Genetic Disease.
Brommel CM, Cooney AL, Sinn PL.Hum Gene Ther. 2020 Sep;31(17-18):985-995. doi: 10.1089/hum.2020.138. Epub 2020 Aug 21.
PMID: 32718227

Extracellular Vesicle-Mediated siRNA Delivery, Protein Delivery, and CFTR Complementation in Well-Differentiated Human Airway Epithelial Cells.
Singh BK, Cooney AL, Krishnamurthy S, Sinn PL.Genes (Basel). 2020 Mar 26;11(4):351. doi: 10.3390/genes11040351.
PMID: 32224868

Intratracheal aerosolization of viral vectors to newborn pig airways.
Cooney AL, Sinn PL.Biotechniques. 2020 May;68(5):235-239. doi: 10.2144/btn-2019-0150. Epub 2020 Mar 6.
PMID: 32141776

Measles Virus Ribonucleoprotein Complexes Rapidly Spread across Well-Differentiated Primary Human Airway Epithelial Cells along F-Actin Rings.
Singh BK, Pfaller CK, Cattaneo R, Sinn PL.mBio. 2019 Nov 26;10(6):e02434-19. doi: 10.1128/mBio.02434-19.
PMID: 31772054

Enhanced tropism of species B1 adenoviral-based vectors for primary airway epithelial cells.
Li N, Cooney AL, Zhang W, Ehrhardt A, Sinn PL.
Mol Ther Meth Clin Devel. 2019; 14:228-236.
PMID: 31417941.

Novel AAV-mediated gene delivery system corrects CFTR function in pigs.
Cooney AL, Thornell IM, Singh BK, Shah VS, Tang XX, Stoltz DA, McCray PB Jr., Zabner J, Sinn PL.
Am J Respir Cell Mol Biol. 2019. Epub ahead of print Jun 11.
PMID: 31184507.

Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward.
Cooney AL, McCray PB Jr, Sinn PL.
Genes (Basel). 2018 Nov 7;9(11). pii: E538. doi: 10.3390/genes9110538. Review.
PMID:30405068

Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.
Cooney AL, Singh BK, Loza LM, Thornell IM, Hippee CE, Powers LS, Ostedgaard LS, Meyerholz DK, Wohlford-Lenane C, Stoltz DA, B McCray P Jr, Sinn PL.
Nucleic Acids Res. 2018 Oct 12;46(18):9591-9600. doi: 10.1093/nar/gky773.
PMID:30165523

Long-term correction of hemophilia A mice following lentiviral mediated delivery of an optimized canine factor VIII gene.
Staber JM, Pollpeter MJ, Anderson CG, Burrascano M, Cooney AL, Sinn PL, Rutkowski DT, Raschke WC, McCray PB.
Gene Ther. 2017 Nov;24(11):742-748. doi: 10.1038/gt.2017.67. Epub 2017 Sep 14.
PMID:28905885

Novel GP64 envelope variants for improved delivery to human airway epithelial cells.
Sinn PL, Hwang BY, Li N, Ortiz JLS, Shirazi E, Parekh KR, Cooney AL, Schaffer DV, McCray PB Jr.
Gene Ther. 2017 Oct;24(10):674-679. doi: 10.1038/gt.2017.78. Epub 2017 Sep 7.
PMID:28880020

Lentiviral Vectors Pseudotyped with Filoviral Glycoproteins.
Sinn PL, Coffin JE, Ayithan N, Holt KH, Maury W.
Methods Mol Biol. 2017;1628:65-78. doi: 10.1007/978-1-4939-7116-9_5.
PMID:28573611

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.
Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Abou Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, Welsh MJ, Sinn PL, Schaffer DV, Zabner J.
JCI Insight. 2016 Sep 8;1(14):e88728.
PMID: 27699238

Lentiviral-mediated phenotypic correction of cystic fibrosis pigs.
Cooney AL, Abou Alaiwa MH, Shah VS, Bouzek DC, Stroik MR, Powers LS, Gansemer ND, Meyerholz DK, Welsh MJ, Stoltz DA, Sinn PL, McCray PB Jr.
JCI Insight. 2016 Sep 8;1(14). pii: e88730.
PMID: 27656681

Cell-to-Cell Contact and Nectin-4 Govern Spread of Measles Virus from Primary Human Myeloid Cells to Primary Human Airway Epithelial Cells.
Singh BK, Li N, Mark AC, Mateo M, Cattaneo R, Sinn PL.
J Virol. 2016 Jul 11;90(15):6808-17. doi: 10.1128/JVI.00266-16.
PMID: 27194761

Human, Pig, and Mouse Interferon-Induced Transmembrane Proteins Partially Restrict Pseudotyped Lentiviral Vectors.
Hornick AL, Li N, Oakland M, McCray PB Jr, Sinn PL.
Hum Gene Ther. 2016 May;27(5):354-62. doi: 10.1089/hum.2015.156.
PMID: 27004832

Connections matter--how viruses use cell–cell adhesion components.
Mateo M, Generous A, Sinn PL, Cattaneo R.
J Cell Sci. 2015 Feb 1;128(3):431-9. Review.
PMID: 26046138

The Nectin-4/Afadin Protein Complex and Intercellular Membrane Pores Contribute to Rapid Spread of Measles Virus in Primary Human Airway Epithelia.
Singh BK, Hornick AL, Krishnamurthy S, Locke AC, Mendoza CA, Mateo M, Miller-Hunt CL, Cattaneo R, Sinn PL.
J Virol. 2015 Jul;89(14):7089-96. doi: 10.1128/JVI.00821-15. Epub 2015 Apr 29. Erratum in: J Virol. 2016 Mar 15;90(6):3278.
PMID: 25926640

Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy.
Yan Z, Stewart ZA, Sinn PL, Olsen JC, Hu J, McCray PB Jr, Engelhardt JF.
Hum Gene Ther Clin Dev. 2015 Mar;26(1):38-49. doi: 10.1089/humc.2014.154. Epub 2015 Feb 12.
PMID:25675143

Hybrid Nonviral/Viral Vector Systems for Improved piggyBac DNA Transposon In Vivo Delivery. 
Cooney AL, Singh BK, Sinn PL.
Mol Ther. 2015 Apr;23(4):667-74. doi: 10.1038/mt.2014.254. Epub 2015 Jan 5.
PMID: 25557623

Different roles of the three loops forming the adhesive interface of nectin-4 in measles virus binding and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1. 
Mateo M, Navaratnarajah CK, Willenbring RC, Maroun JW, Iankov I, Lopez M, Sinn PL, Cattaneo R.
J Virol. 2014 Dec;88(24):14161-71. doi: 10.1128/JVI.02379-14. Epub 2014 Oct 1.
PMID: 25275122

Integrin α6β4 identifies human distal lung epithelial progenitor cells with potential as a cell-based therapy for cystic fibrosis lung disease. 
Li X, Rossen N, Sinn PL, Hornick AL, Steines BR, Karp PH, Ernst SE, Adam RJ, Moninger TO, Levasseur DN, Zabner J.
PLoS One. 2013 Dec 12;8(12):e83624. doi: 10.1371/journal.pone.0083624. eCollection 2013.
PMID: 24349537

piggyBac transposase tools for genome engineering. 
Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan SJ, Joung JK, McCray PB Jr, Bushman FD, Sinn PL, Craig NL.
Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2279-87. doi: 10.1073/pnas.1305987110. Epub 2013 May 30.
PMID: 23723351

Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors. 
Oakland M, Maury W, McCray PB Jr, Sinn PL.
Mol Ther Nucleic Acids. 2013 Jan 29;2:e69. doi: 10.1038/mtna.2012.60.
PMID: 23360952

Lentiviral vector gene transfer to porcine airways. 
Sinn PL, Cooney AL, Oakland M, Dylla DE, Wallen TJ, Pezzulo AA, Chang EH, McCray PB Jr.
Mol Ther Nucleic Acids. 2012 Nov 27;1:e56. doi: 10.1038/mtna.2012.47.
PMID: 23187455

Transcriptional targeting in the airway using novel gene regulatory elements. 
Burnight ER, Wang G, McCray PB Jr, Sinn PL.
Am J Respir Cell Mol Biol. 2012 Aug;47(2):227-33. doi: 10.1165/rcmb.2011-0444OC. Epub 2012 Mar 23.
PMID: 22447971

Advances in cell and gene-based therapies for cystic fibrosis lung disease. 
Oakland M, Sinn PL, McCray PB Jr.
Mol Ther. 2012 Jun;20(6):1108-15. doi: 10.1038/mt.2012.32. Epub 2012 Feb 28. Review.
PMID: 22371844

Adherens junction protein nectin-4 is the epithelial receptor for measles virus. 
Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, Ramachandran S, McCray PB Jr, Cichutek K, von Messling V, Lopez M, Cattaneo R.
Nature. 2011 Nov 2;480(7378):530-3. doi: 10.1038/nature10639.
PMID: 22048310

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. 
Kondratowicz AS, Lennemann NJ, Sinn PL, Davey RA, Hunt CL, Moller-Tank S, Meyerholz DK, Rennert P, Mullins RF, Brindley M, Sandersfeld LM, Quinn K, Weller M, McCray PB Jr, Chiorini J, Maury W.
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8426-31. doi: 10.1073/pnas.1019030108. Epub 2011 May 2.
PMID: 21536871

Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. 
Brindley MA, Hunt CL, Kondratowicz AS, Bowman J, Sinn PL, McCray PB Jr, Quinn K, Weller ML, Chiorini JA, Maury W.
Virology. 2011 Jul 5;415(2):83-94. doi: 10.1016/j.virol.2011.04.002. Epub 2011 May 6.
PMID: 21529875

Genetic therapies for cystic fibrosis lung disease. 
Sinn PL, Anthony RM, McCray PB Jr.
Hum Mol Genet. 2011 Apr 15;20(R1):R79-86. doi: 10.1093/hmg/ddr104. Epub 2011 Mar 21. Review.
PMID: 21422098

The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways. 
Griesenbach U, Meng C, Farley R, Wasowicz MY, Munkonge FM, Chan M, Stoneham C, Sumner-Jones SG, Pringle IA, Gill DR, Hyde SC, Stevenson B, Holder E, Ban H, Hasegawa M, Cheng SH, Scheule RK, Sinn PL, McCray PB Jr, Alton EW.
Biomaterials. 2010 Mar;31(9):2665-72. doi: 10.1016/j.biomaterials.2009.12.005. Epub 2009 Dec 21.
PMID: 20022367

Progress and prospects: prospects of repeated pulmonary administration of viral vectors. 
Sinn PL, Burnight ER, McCray PB Jr.
Gene Ther. 2009 Sep;16(9):1059-65. doi: 10.1038/gt.2009.87. Epub 2009 Jul 30. Review.
PMID: 19641533

Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors. 
Quinn K, Brindley MA, Weller ML, Kaludov N, Kondratowicz A, Hunt CL, Sinn PL, McCray PB Jr, Stein CS, Davidson BL, Flick R, Mandell R, Staplin W, Maury W, Chiorini JA.
J Virol. 2009 Oct;83(19):10176-86. doi: 10.1128/JVI.00422-09. Epub 2009 Jul 22.
PMID: 19625394

Lentivirus vector can be readministered to nasal epithelia without blocking immune responses. 
Sinn PL, Arias AC, Brogden KA, McCray PB Jr.
J Virol. 2008 Nov;82(21):10684-92. doi: 10.1128/JVI.00227-08. Epub 2008 Sep 3.
PMID: 18768988

Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. 
Leonard VH, Sinn PL, Hodge G, Miest T, Devaux P, Oezguen N, Braun W, McCray PB Jr, McChesney MB, Cattaneo R.
J Clin Invest. 2008 Jul;118(7):2448-58. doi: 10.1172/JCI35454.
PMID: 18568079

In vivo imaging of gene transfer to the respiratory tract. 
Griesenbach U, Meng C, Farley R, Cheng SH, Scheule RK, Davies MH, Wolstenholme-Hogg PC, ten Hove W, van der Hoeven P, Sinn PL, McCray PB Jr, Inoue M, Geddes DM, Hasegawa M, Frankel G, Wiles S, Alton EW.
Biomaterials. 2008 Apr;29(10):1533-40. Epub 2007 Dec 21.
PMID: 18155138