Dr. Sinn is the director of the Viral Vector Core at the University of Iowa. The core serves investigators world-wide and produces viral vectors for studies in the lung, eye, brain, liver, heart, muscle, cardiovascular, and neuromuscular systems. As such, the Viral Vector Core staff members are active participants in the development of gene transfer technologies in the cancer, neurobiology, cardiovascular, macular degeneration, and cystic fibrosis centers. The overall objective of the vector core is to support investigators in gene transfer technologies. This includes consultation, development of novel vectors, collaborative testing of vectors for function and purity, and routine vector preparations.

Viral Vector Core Services

• Construct, purify, and perform quality control of: recombinant adenovirus; helper-dependent adenovirus; adeno-associated virus; lentivirus; moloney murine retrovirus; baculovirus; vaccinia virus
• Consultations for individual project requirements
• Design, build, and produce novel vectors
• Maintain and distribute stocks of recombinant reporter viruses
• Cloning expression cassettes into vector shuttles